Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8 million annually. Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis drug rifampin (Rif). We report crystal structures of Mtb RNAP, alone and in complex with Rif, at 3.8–4.4 Å resolution....

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Lin, Wei, Mandal, Soma, Degen, David, Liu, Yu, Ebright, Yon W., Li, Shengjian, Feng, Yu, Zhang, Yu, Mandal, Sukhendu, Jiang, Yi, Liu, Shuang, Gigliotti, Matthew, Talaue, Meliza, Connell, Nancy, Das, Kalyan, Arnold, Eddy, Ebright, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438085/
https://ncbi.nlm.nih.gov/pubmed/28392175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.001
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