Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8 million annually. Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis drug rifampin (Rif). We report crystal structures of Mtb RNAP, alone and in complex with Rif, at 3.8–4.4 Å resolution....

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Lin, Wei, Mandal, Soma, Degen, David, Liu, Yu, Ebright, Yon W., Li, Shengjian, Feng, Yu, Zhang, Yu, Mandal, Sukhendu, Jiang, Yi, Liu, Shuang, Gigliotti, Matthew, Talaue, Meliza, Connell, Nancy, Das, Kalyan, Arnold, Eddy, Ebright, Richard H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438085/
https://ncbi.nlm.nih.gov/pubmed/28392175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.001
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