Transcription inhibition by the depsipeptide antibiotic salinamide A

We report that bacterial RNA polymerase (RNAP) is the functional cellular target of the depsipeptide antibiotic salinamide A (Sal), and we report that Sal inhibits RNAP through a novel binding site and mechanism. We show that Sal inhibits RNA synthesis in cells and that mutations that confer Sal-res...

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Detalhes bibliográficos
Main Authors: Degen, David, Feng, Yu, Zhang, Yu, Ebright, Katherine Y, Ebright, Yon W, Gigliotti, Matthew, Vahedian-Movahed, Hanif, Mandal, Sukhendu, Talaue, Meliza, Connell, Nancy, Arnold, Eddy, Fenical, William, Ebright, Richard H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029172/
https://ncbi.nlm.nih.gov/pubmed/24843001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02451
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