STRUCTURAL BASIS OF TRANSCRIPTION INHIBITION BY FIDAXOMICIN (LIPIARMYCIN A3)

Fidaxomicin is an antibacterial drug in clinical use in treatment of Clostridium difficile diarrhea. The active ingredient of the antibacterial drug fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting bacterial RNA polymerase (RNAP). Here, we report a cryo-EM structure of Mycobacterium tuberc...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Lin, Wei, Das, Kalyan, Degen, David, Mazumder, Abhishek, Duchi, Diego, Wang, Dongye, Ebright, Yon W., Ebright, Richard Y., Sineva, Elena, Gigliotti, Matthew, Srivastava, Aashish, Mandal, Sukhendu, Jiang, Yi, Liu, Yu, Yin, Ruiheng, Zhang, Zhening, Eng, Edward T., Thomas, Dennis, Donadio, Stefano, Zhang, Haibo, Zhang, Changsheng, Kapanidis, Achillefs N., Ebright, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205224/
https://ncbi.nlm.nih.gov/pubmed/29606590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.026
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