STRUCTURAL BASIS OF TRANSCRIPTION INHIBITION BY FIDAXOMICIN (LIPIARMYCIN A3)

Fidaxomicin is an antibacterial drug in clinical use in treatment of Clostridium difficile diarrhea. The active ingredient of the antibacterial drug fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting bacterial RNA polymerase (RNAP). Here, we report a cryo-EM structure of Mycobacterium tuberc...

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Publicat a:Mol Cell
Autors principals: Lin, Wei, Das, Kalyan, Degen, David, Mazumder, Abhishek, Duchi, Diego, Wang, Dongye, Ebright, Yon W., Ebright, Richard Y., Sineva, Elena, Gigliotti, Matthew, Srivastava, Aashish, Mandal, Sukhendu, Jiang, Yi, Liu, Yu, Yin, Ruiheng, Zhang, Zhening, Eng, Edward T., Thomas, Dennis, Donadio, Stefano, Zhang, Haibo, Zhang, Changsheng, Kapanidis, Achillefs N., Ebright, Richard H.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205224/
https://ncbi.nlm.nih.gov/pubmed/29606590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.026
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