STRUCTURAL BASIS OF TRANSCRIPTION INHIBITION BY FIDAXOMICIN (LIPIARMYCIN A3)

Fidaxomicin is an antibacterial drug in clinical use in treatment of Clostridium difficile diarrhea. The active ingredient of the antibacterial drug fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting bacterial RNA polymerase (RNAP). Here, we report a cryo-EM structure of Mycobacterium tuberc...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Lin, Wei, Das, Kalyan, Degen, David, Mazumder, Abhishek, Duchi, Diego, Wang, Dongye, Ebright, Yon W., Ebright, Richard Y., Sineva, Elena, Gigliotti, Matthew, Srivastava, Aashish, Mandal, Sukhendu, Jiang, Yi, Liu, Yu, Yin, Ruiheng, Zhang, Zhening, Eng, Edward T., Thomas, Dennis, Donadio, Stefano, Zhang, Haibo, Zhang, Changsheng, Kapanidis, Achillefs N., Ebright, Richard H.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205224/
https://ncbi.nlm.nih.gov/pubmed/29606590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.026
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