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4-Acetoxyphenol Prevents RPE Oxidative Stress–Induced Necrosis by Functioning as an NRF2 Stabilizer

PURPOSE: Oxidative stress has been suggested to be a major risk factor for the pathogenesis of AMD. Retinal pigment epithelial (RPE) cells are essential for maintaining the homeostasis of the retina, and RPE cell death and the resultant photoreceptor apoptosis have been observed in dry AMD, especial...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Hanus, Jakub, Kolkin, Alexander, Chimienti, Julia, Botsay, Sara, Wang, Shusheng
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525684/
https://ncbi.nlm.nih.gov/pubmed/26241392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16401
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