Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased levels of reactive oxygen species (ROS) and mitochondrial structural and metabolic dysfu...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Zamponi, Emiliano, Zamponi, Nahuel, Coskun, Pinar, Quassollo, Gonzalo, Lorenzo, Alfredo, Cannas, Sergio A., Pigino, Gustavo, Chialvo, Dante R., Gardiner, Katheleen, Busciglio, Jorge, Helguera, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156351/
https://ncbi.nlm.nih.gov/pubmed/30028071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12812
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