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A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

BACKGROUND: Down's syndrome (DS) is the most common genetic cause of mental retardation. Reduced number and aberrant architecture of dendritic spines are common features of DS neuropathology. However, the mechanisms involved in DS spine alterations are not known. In addition to a relevant role...

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Detalhes bibliográficos
Main Authors: Garcia, Octavio, Torres, Maria, Helguera, Pablo, Coskun, Pinar, Busciglio, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996288/
https://ncbi.nlm.nih.gov/pubmed/21152035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014200
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