The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

PURPOSE: To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial bioenergetics, and senescence. METHODS: Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal...

Full description

Saved in:
Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Sreekumar, Parameswaran G., Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H., Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2016
Subjects:
Retinal Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811181/
https://ncbi.nlm.nih.gov/pubmed/26990160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17053
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items