Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis

The 5′ cap structures of eukaryotic mRNAs are important for RNA stability and protein translation. Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases (2′-O-MTase) to autonomously modify their mRNAs and carry a cap-1 structure (m7GpppNm) at the 5′ end, the...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Wang, Yi, Sun, Ying, Wu, Andong, Xu, Shan, Pan, Ruangang, Zeng, Cong, Jin, Xu, Ge, Xingyi, Shi, Zhengli, Ahola, Tero, Chen, Yu, Guo, Deyin
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524257/
https://ncbi.nlm.nih.gov/pubmed/26041293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00948-15
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