Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis

The 5′ cap structures of eukaryotic mRNAs are important for RNA stability and protein translation. Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases (2′-O-MTase) to autonomously modify their mRNAs and carry a cap-1 structure (m7GpppNm) at the 5′ end, the...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wang, Yi, Sun, Ying, Wu, Andong, Xu, Shan, Pan, Ruangang, Zeng, Cong, Jin, Xu, Ge, Xingyi, Shi, Zhengli, Ahola, Tero, Chen, Yu, Guo, Deyin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524257/
https://ncbi.nlm.nih.gov/pubmed/26041293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00948-15
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