Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In this report, we used a yeast genetic system to functionally screen for the cap-form...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Yu, Cai, Hui, Pan, Ji'an, Xiang, Nian, Tien, Po, Ahola, Tero, Guo, Deyin
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651275/
https://ncbi.nlm.nih.gov/pubmed/19208801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808790106
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