Natural product (−)‐gossypol inhibits colon cancer cell growth by targeting RNA‐binding protein Musashi‐1

Musashi‐1 (MSI1) is an RNA‐binding protein that acts as a translation activator or repressor of target mRNAs. The best‐characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. Additional MSI1 targets include the mRNAs for the tumor suppressor protein APC th...

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Dettagli Bibliografici
Pubblicato in:Mol Oncol
Autori principali: Lan, Lan, Appelman, Carl, Smith, Amber R., Yu, Jia, Larsen, Sarah, Marquez, Rebecca T., Liu, Hao, Wu, Xiaoqing, Gao, Philip, Roy, Anuradha, Anbanandam, Asokan, Gowthaman, Ragul, Karanicolas, John, De Guzman, Roberto N., Rogers, Steven, Aubé, Jeffrey, Ji, Min, Cohen, Robert S., Neufeld, Kristi L., Xu, Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523432/
https://ncbi.nlm.nih.gov/pubmed/25933687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.03.014
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