Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction

RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include Numb, APC, and P21(WAF-1), key regulators of Notch/Wnt s...

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Publicado en:Cancers (Basel)
Main Authors: Lan, Lan, Liu, Jiajun, Xing, Minli, Smith, Amber R., Wang, Jinan, Wu, Xiaoqing, Appelman, Carl, Li, Ke, Roy, Anuradha, Gowthaman, Ragul, Karanicolas, John, Somoza, Amber D., Wang, Clay C. C., Miao, Yinglong, De Guzman, Roberto, Oakley, Berl R., Neufeld, Kristi L., Xu, Liang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463734/
https://ncbi.nlm.nih.gov/pubmed/32784494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082221
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