Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

BACKGROUND: The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signaling. MSI1 binds to and negatively regulates translation o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Lan, Lan, Liu, Hao, Smith, Amber R., Appelman, Carl, Yu, Jia, Larsen, Sarah, Marquez, Rebecca T., Wu, Xiaoqing, Liu, Frank Y., Gao, Philip, Gowthaman, Ragul, Karanicolas, John, De Guzman, Roberto N., Rogers, Steven, Aubé, Jeffrey, Neufeld, Kristi L., Xu, Liang
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086024/
https://ncbi.nlm.nih.gov/pubmed/30097032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4704-z
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