Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

BACKGROUND: The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signaling. MSI1 binds to and negatively regulates translation o...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Lan, Lan, Liu, Hao, Smith, Amber R., Appelman, Carl, Yu, Jia, Larsen, Sarah, Marquez, Rebecca T., Wu, Xiaoqing, Liu, Frank Y., Gao, Philip, Gowthaman, Ragul, Karanicolas, John, De Guzman, Roberto N., Rogers, Steven, Aubé, Jeffrey, Neufeld, Kristi L., Xu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086024/
https://ncbi.nlm.nih.gov/pubmed/30097032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4704-z
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