Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction

RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include Numb, APC, and P21(WAF-1), key regulators of Notch/Wnt s...

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Dades bibliogràfiques
Publicat a:Cancers (Basel)
Autors principals: Lan, Lan, Liu, Jiajun, Xing, Minli, Smith, Amber R., Wang, Jinan, Wu, Xiaoqing, Appelman, Carl, Li, Ke, Roy, Anuradha, Gowthaman, Ragul, Karanicolas, John, Somoza, Amber D., Wang, Clay C. C., Miao, Yinglong, De Guzman, Roberto, Oakley, Berl R., Neufeld, Kristi L., Xu, Liang
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463734/
https://ncbi.nlm.nih.gov/pubmed/32784494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082221
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