Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain

BACKGROUND: Tau hyperphosphorylation plays a critical role in neurodegenerative diseases [EMBO Mol Med. 6:1142-60, 2014; Annu Rev Neurosci. 24:1121-59, 2001]. Recent evidence has shown that Akt is down-regulated in AD [J Pathol. 225:54-62, 2011]. However, it remained unknown which pathological proce...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Wang, Long, Cheng, Shanshan, Yin, Zhenyu, Xu, Congyu, Lu, Shuangshuang, Hou, Jinxing, Yu, Tingting, Zhu, Xiaolei, Zou, Xiaoyan, Peng, Ying, Xu, Yun, Yang, Zhongzhou, Chen, Guiquan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521471/
https://ncbi.nlm.nih.gov/pubmed/26227811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0030-y
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