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APOE4 promotes nigral tau hyperphosphorylation through cholesterol in atherosclerosis
Abstract Nigral tau hyperphosphorylation has been implicated as an initiation of nigrostriatal dopaminergic neurodegeneration. Apolipoprotein epsilon 4 allele (APOE4) is a common risk factor of Parkinson’s disease (PD) and atherosclerosis (AS). Whether APOE4 carriers exhibited higher levels of nigra...
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| Huvudupphovsmän: | , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2025-10-01
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| Serie: | Cell Death Discovery |
| Länkar: | https://doi.org/10.1038/s41420-025-02778-1 |
| Taggar: |
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