Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance

Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced activation of IL-1 receptor-ass...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Murphy, Michael, Xiong, Yanbao, Pattabiraman, Goutham, Qiu, Fu, Medvedev, Andrei E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521043/
https://ncbi.nlm.nih.gov/pubmed/26082489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.640128
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