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R753Q Polymorphism Inhibits Toll-like Receptor (TLR) 2 Tyrosine Phosphorylation, Dimerization with TLR6, and Recruitment of Myeloid Differentiation Primary Response Protein 88

The R753Q polymorphism in the Toll-IL-1 receptor domain of Toll-like receptor 2 (TLR2) has been linked to increased incidence of tuberculosis and other infectious diseases, but the mechanisms by which it affects TLR2 functions are unclear. Here, we studied the impact of the R753Q polymorphism on TLR...

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Библиографические подробности
Главные авторы: Xiong, Yanbao, Song, Chang, Snyder, Greg A., Sundberg, Eric J., Medvedev, Andrei E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488101/
https://ncbi.nlm.nih.gov/pubmed/22992740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375493
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