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R753Q Polymorphism Inhibits Toll-like Receptor (TLR) 2 Tyrosine Phosphorylation, Dimerization with TLR6, and Recruitment of Myeloid Differentiation Primary Response Protein 88

The R753Q polymorphism in the Toll-IL-1 receptor domain of Toll-like receptor 2 (TLR2) has been linked to increased incidence of tuberculosis and other infectious diseases, but the mechanisms by which it affects TLR2 functions are unclear. Here, we studied the impact of the R753Q polymorphism on TLR...

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Detalhes bibliográficos
Main Authors: Xiong, Yanbao, Song, Chang, Snyder, Greg A., Sundberg, Eric J., Medvedev, Andrei E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488101/
https://ncbi.nlm.nih.gov/pubmed/22992740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375493
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