Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance

Eitemau Tebyg

• Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling
  gan: Murphy, Michael B., et al.
  Cyhoeddwyd: (2015)
• IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance
  gan: Xiong, Yanbao, et al.
  Cyhoeddwyd: (2013)
• Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20
  gan: Xiong, Yanbao, et al.
  Cyhoeddwyd: (2011)
• Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases
  gan: Xiong, Yanbao, et al.
  Cyhoeddwyd: (2016)
• R753Q Polymorphism Inhibits Toll-like Receptor (TLR) 2 Tyrosine Phosphorylation, Dimerization with TLR6, and Recruitment of Myeloid Differentiation Primary Response Protein 88
  gan: Xiong, Yanbao, et al.
  Cyhoeddwyd: (2012)