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Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance
Lopinavir (LPV) is a second generation HIV-1 protease inhibitor. Drug resistance has rapidly emerged against LPV US FDA approved it on September 15, 2000. Mutations at residues 32I, L33F, 46I, 47A, I54V, V82A, I84V and L90M render the protease drug resistant against LPV. We report the crystal struct...
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| Veröffentlicht in: | Biochem Biophys Res Commun |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520426/ https://ncbi.nlm.nih.gov/pubmed/23792096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.06.027 |
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