Loss of Sparc in p 53‐null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival

Both the induction of SPARC expression and the loss of the p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore, during glioma formation, the upregulation of SPARC may coope...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Brain Pathol
Autori principali: Thomas, Stacey L., Schultz, Chad R., Mouzon, Ezekiell, Golembieski, William A., Naili, Reima El, Radakrishnan, Archanna, Lemke, Nancy, Poisson, Laila M., Gutiérrez, Jorge A., Cottingham, Sandra, Rempel, Sandra A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520390/
https://ncbi.nlm.nih.gov/pubmed/24862407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12161
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