PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling

SPARC (secreted protein acidic and rich in cysteine) is expressed in all grades of astrocytoma, including glioblastoma (GBM). SPARC suppresses glioma growth but promotes migration and invasion by mediating integrin and growth factor receptor-regulated kinases and their downstream effectors. PTEN (ph...

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Bibliografske podrobnosti
Main Authors: Thomas, Stacey L., Alam, Ridwan, Lemke, Nancy, Schultz, Lonni R., Gutiérrez, Jorge A., Rempel, Sandra A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940688/
https://ncbi.nlm.nih.gov/pubmed/20472716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq048
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