PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling

SPARC (secreted protein acidic and rich in cysteine) is expressed in all grades of astrocytoma, including glioblastoma (GBM). SPARC suppresses glioma growth but promotes migration and invasion by mediating integrin and growth factor receptor-regulated kinases and their downstream effectors. PTEN (ph...

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Библиографические подробности
Главные авторы: Thomas, Stacey L., Alam, Ridwan, Lemke, Nancy, Schultz, Lonni R., Gutiérrez, Jorge A., Rempel, Sandra A.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2010
Предметы:
Basic and Translational Investigations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940688/
https://ncbi.nlm.nih.gov/pubmed/20472716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq048
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