PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma

BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC) is overexpressed in astrocytomas (World Health Organization grades II–IV). We previously demonstrated that SPARC promotes glioma migration and invasion—in part, by activating the P38 mitogen-activated protein kinase (MAPK)–heat shock p...

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Hlavní autoři: Alam, Ridwan, Schultz, Chad R., Golembieski, William A., Poisson, Laila M., Rempel, Sandra A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607267/
https://ncbi.nlm.nih.gov/pubmed/23382286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos326
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