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PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma
BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC) is overexpressed in astrocytomas (World Health Organization grades II–IV). We previously demonstrated that SPARC promotes glioma migration and invasion—in part, by activating the P38 mitogen-activated protein kinase (MAPK)–heat shock p...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607267/ https://ncbi.nlm.nih.gov/pubmed/23382286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos326 |
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