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SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion

Glioblastomas are heterogeneous tumors displaying regions of necrosis, proliferation, angiogenesis, apoptosis and invasion. SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell deadhesion from matrix, is upregulated in gliomas (Grades II–IV)...

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Bibliografski detalji
Glavni autori: Yunker, Christopher K, Golembieski, William, Lemke, Nancy, Schultz, Chad R, Cazacu, Simona, Brodie, Chaya, Rempel, Sandra A
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644882/
https://ncbi.nlm.nih.gov/pubmed/18350569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23450
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