SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion

Glioblastomas are heterogeneous tumors displaying regions of necrosis, proliferation, angiogenesis, apoptosis and invasion. SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell deadhesion from matrix, is upregulated in gliomas (Grades II–IV)...

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Bibliographische Detailangaben
Hauptverfasser: Yunker, Christopher K, Golembieski, William, Lemke, Nancy, Schultz, Chad R, Cazacu, Simona, Brodie, Chaya, Rempel, Sandra A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Subscription Services, Inc., A Wiley Company 2008
Schlagworte:
Cancer Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644882/
https://ncbi.nlm.nih.gov/pubmed/18350569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23450
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