Proteolysis of the Matricellular Protein Hevin by Matrix Metalloproteinase-3 Produces a SPARC-like Fragment (SLF) Associated with Neovasculature in a Murine Glioma Model

The matricellular SPARC-family member hevin (Sparc-like 1/SPARCL-1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. Based on sequence similarity, we hypothesized that proteolytic digestion of hevin would result in SPARC-like fragments (SLF) th...

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Main Authors: Weaver, Matt, Workman, Gail, Schultz, Chad R., Lemke, Nancy, Rempel, Sandra A., Sage, E. Helene
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188378/
https://ncbi.nlm.nih.gov/pubmed/21688302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23235
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