Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

Astrocytes regulate synaptic connectivity in the CNS through secreted signals. Here we identified two astrocyte-secreted proteins, hevin and SPARC, as regulators of excitatory synaptogenesis in vitro and in vivo. Hevin induces the formation of synapses between cultured rat retinal ganglion cells. SP...

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Main Authors: Kucukdereli, Hakan, Allen, Nicola J., Lee, Anthony T., Feng, Ava, Ozlu, M. Ilcim, Conatser, Laura M., Chakraborty, Chandrani, Workman, Gail, Weaver, Matthew, Sage, E. Helene, Barres, Ben A., Eroglu, Cagla
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156217/
https://ncbi.nlm.nih.gov/pubmed/21788491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104977108
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