SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion

Glioblastomas are heterogeneous tumors displaying regions of necrosis, proliferation, angiogenesis, apoptosis and invasion. SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell deadhesion from matrix, is upregulated in gliomas (Grades II–IV)...

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Detalhes bibliográficos
Main Authors: Yunker, Christopher K, Golembieski, William, Lemke, Nancy, Schultz, Chad R, Cazacu, Simona, Brodie, Chaya, Rempel, Sandra A
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2008
Assuntos:
Cancer Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644882/
https://ncbi.nlm.nih.gov/pubmed/18350569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23450
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