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UVB induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
Ultraviolet (UV) radiation in sunlight is the major environmental cause of skin cancer. PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a proven critical tumor suppressor. We report here that UVB down-regulates PTEN in primary human keratinocytes, human HaCaT keratinocytes, and mou...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813408/ https://ncbi.nlm.nih.gov/pubmed/19881543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.357 |
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