LOSS OF SPARC IN P53-NULL ASTROCYTES PROMOTES MACROPHAGE ACTIVATION AND PHAGOCYTOSIS RESULTING IN DECREASED TUMOR SIZE AND TUMOR CELL SURVIVAL

BACKGROUND: Both enhanced SPARC expression and the loss of p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore, during glioma formation, the upregulation of SPARC may coope...

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Main Authors: Rempel, Sandra A., Thomas, Stacey L., Schultz, Chad R., Mouzon, Ezekiell, Golembieski, William A., El Naila, Reima, Radakrishnan, Archanna, Bobbitt, Kevin R., Lemke, Nancy, Gutiérrez, Jorge A., Poisson, Laila M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144658/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.8
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