GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β–Induced Smad3 Phosphorylation

TGF-β1, via Smad-dependent or Smad-independent signaling, has a central role in the pathogenesis of renal fibrosis. This pathway has been recognized as a potential target for antifibrotic therapy. Here, we identified GQ5, a small molecular phenolic compound isolated from the dried resin of Toxicoden...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Ai, Jun, Nie, Jing, He, Jiangbo, Guo, Qin, Li, Mei, Lei, Ying, Liu, Youhua, Zhou, Zhanmei, Zhu, Fengxin, Liang, Min, Cheng, Yongxian, Hou, Fan Fan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2015
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520163/
https://ncbi.nlm.nih.gov/pubmed/25392233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040363
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