Smad2 Protects against TGF-β/Smad3-Mediated Renal Fibrosis

Smad2 and Smad3 interact and mediate TGF-β signaling. Although Smad3 promotes fibrosis, the role of Smad2 in fibrogenesis is largely unknown. In this study, conditional deletion of Smad2 from the kidney tubular epithelial cells markedly enhanced fibrosis in response to unilateral ureteral obstructio...

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Detalhes bibliográficos
Main Authors: Meng, Xiao Ming, Huang, Xiao Ru, Chung, Arthur C.K., Qin, Wei, Shao, Xinli, Igarashi, Peter, Ju, Wenjun, Bottinger, Erwin P., Lan, Hui Yao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2010
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013519/
https://ncbi.nlm.nih.gov/pubmed/20595680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121244
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