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Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

TGF-β/Smad signaling plays a role in fibrogenesis, but therapies targeting TGF-β are ineffective in treating renal fibrosis. Here, we explored the therapeutic potential of targeting TGF-β-induced microRNA in the progression of renal fibrosis. Microarray analysis and real-time PCR revealed upregulati...

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Hlavní autoři: Zhong, Xiang, Chung, Arthur C.K., Chen, Hai-Yong, Meng, Xiao-Ming, Lan, Hui Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171938/
https://ncbi.nlm.nih.gov/pubmed/21852586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010111168
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