CRFR1 activation protects against cytokine-induced beta cell death

During diabetes development beta cells are exposed to elevated concentrations of proinflammatory cytokines, TNFα and IL-1β which in vitro, induce beta cell death. The class B G-protein-coupled receptors (GPCRs): Corticotropin releasing factor receptor 1 (CRFR1) and CRFR2 are expressed in pancreatic...

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Pubblicato in:J Mol Endocrinol
Autori principali: Blaabjerg, Lykke, Christensen, Gitte L., Matsumoto, Masahito, van der Meulen, Talitha, Huising, Mark O., Billestrup, Nils, Vale, Wylie W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518718/
https://ncbi.nlm.nih.gov/pubmed/25324488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-14-0056
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