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CRFR1 activation protects against cytokine-induced beta cell death
During diabetes development beta cells are exposed to elevated concentrations of proinflammatory cytokines, TNFα and IL-1β which in vitro, induce beta cell death. The class B G-protein-coupled receptors (GPCRs): Corticotropin releasing factor receptor 1 (CRFR1) and CRFR2 are expressed in pancreatic...
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| Publicado no: | J Mol Endocrinol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4518718/ https://ncbi.nlm.nih.gov/pubmed/25324488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-14-0056 |
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