CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

Physiological bone remodeling requires that bone formation by osteoblasts be tightly coupled to bone resorption by osteoclasts. However, relatively little is understood about how this coupling is regulated. Here, we demonstrate that modulation of NF-κB signaling in osteoclasts via a novel activity o...

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Vydáno v:J Exp Med
Hlavní autoři: Greenblatt, Matthew B., Park, Kwang Hwan, Oh, Hwanhee, Kim, Jung-Min, Shin, Dong Yeon, Lee, Jae Myun, Lee, Jin Woo, Singh, Anju, Lee, Ki-young, Hu, Dorothy, Xiao, Changchun, Charles, Julia F., Penninger, Josef M., Lotinun, Sutada, Baron, Roland, Ghosh, Sankar, Shim, Jae-Hyuck
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516796/
https://ncbi.nlm.nih.gov/pubmed/26195726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150407
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