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MEKK2 mediates an alternative β-catenin pathway that promotes bone formation
Proper tuning of β-catenin activity in osteoblasts is required for bone homeostasis, because both increased and decreased β-catenin activity have pathologic consequences. In the classical pathway for β-catenin activation, stimulation with WNT ligands suppresses constitutive phosphorylation of β-cate...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780654/ https://ncbi.nlm.nih.gov/pubmed/26884171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600813113 |
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