MEKK2 mediates an alternative β-catenin pathway that promotes bone formation

Proper tuning of β-catenin activity in osteoblasts is required for bone homeostasis, because both increased and decreased β-catenin activity have pathologic consequences. In the classical pathway for β-catenin activation, stimulation with WNT ligands suppresses constitutive phosphorylation of β-cate...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Greenblatt, Matthew Blake, Shin, Dong Yeon, Oh, Hwanhee, Lee, Ki-Young, Zhai, Bo, Gygi, Steven P., Lotinun, Sutada, Baron, Roland, Liu, Dou, Su, Bing, Glimcher, Laurie H., Shim, Jae-Hyuck
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780654/
https://ncbi.nlm.nih.gov/pubmed/26884171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600813113
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