SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

Coordination between osteoblasts and osteoclasts is required for bone health and homeostasis. Here we show that mice deficient in SMURF2 have severe osteoporosis in vivo. This low bone mass phenotype is accompanied by a pronounced increase in osteoclast numbers, although Smurf2-deficient osteoclasts...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Xu, Zhan, Greenblatt, Matthew B., Yan, Guang, Feng, Heng, Sun, Jun, Lotinun, Sutada, Brady, Nicholas, Baron, Roland, Glimcher, Laurie H., Zou, Weiguo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321737/
https://ncbi.nlm.nih.gov/pubmed/28216630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14570
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