CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

Physiological bone remodeling requires that bone formation by osteoblasts be tightly coupled to bone resorption by osteoclasts. However, relatively little is understood about how this coupling is regulated. Here, we demonstrate that modulation of NF-κB signaling in osteoclasts via a novel activity o...

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Publicado en:J Exp Med
Main Authors: Greenblatt, Matthew B., Park, Kwang Hwan, Oh, Hwanhee, Kim, Jung-Min, Shin, Dong Yeon, Lee, Jae Myun, Lee, Jin Woo, Singh, Anju, Lee, Ki-young, Hu, Dorothy, Xiao, Changchun, Charles, Julia F., Penninger, Josef M., Lotinun, Sutada, Baron, Roland, Ghosh, Sankar, Shim, Jae-Hyuck
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516796/
https://ncbi.nlm.nih.gov/pubmed/26195726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150407
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