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Disruption of c-Kit Signaling in Kit(W-sh/W-sh) Growing Mice Increases Bone Turnover

c-Kit tyrosine kinase receptor has been identified as a regulator of bone homeostasis. The c-Kit loss-of-function mutations in WBB6F1/J-Kit(W/W-v) mice result in low bone mass. However, these mice are sterile and it is unclear whether the observed skeletal phenotype is secondary to a sex hormone def...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Lotinun, Sutada, Krishnamra, Nateetip
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985756/
https://ncbi.nlm.nih.gov/pubmed/27527615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31515
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