Mast Cell-Deficient W-sash c-kit Mutant Kit(W-sh/W-sh) Mice as a Model for Investigating Mast Cell Biology in Vivo

Mice carrying certain mutations in the white spotting (W) locus (ie, c-kit) exhibit reduced c-kit tyrosine kinase-dependent signaling that results in mast cell deficiency and other phenotypic abnormalities. The c-kit mutations in Kit(W/W-v) mice impair melanogenesis and result in anemia, sterility,...

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Autores principales: Grimbaldeston, Michele A., Chen, Ching-Cheng, Piliponsky, Adrian M., Tsai, Mindy, Tam, See-Ying, Galli, Stephen J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2005
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Original Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698741/
https://ncbi.nlm.nih.gov/pubmed/16127161
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