Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma

Patients with pancreatic cancer have a poor survival rate, and new therapeutic strategies are needed. Epithelial cell adhesion molecule (EpCAM), suggested as a marker for cancer stem cells, is over-expressed on most pancreatic tumour cells but not on normal cells and may be an ideal therapeutic targ...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Salnikov, Alexei V, Groth, Ariane, Apel, Anja, Kallifatidis, Georgios, Beckermann, Benjamin M, Khamidjanov, Akmal, Ryschich, Eduard, Büchler, Markus W, Herr, Ingrid, Moldenhauer, Gerhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2009
Schlagworte:
Molecular Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516549/
https://ncbi.nlm.nih.gov/pubmed/20196789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00723.x
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