Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

DNA topoisomerase I (TOP1) levels of several human neoplasms are higher than those of normal tissues. TOP1 inhibitors are widely used in treating conventional therapy-resistant ovarian cancers. However, patients may develop resistance to TOP1 inhibitors, hampering chemotherapy success. In this study...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Yu-Chieh, Lee, Chii-Hong, Tsai, Hsiang-Ping, An, Herng-Wei, Lee, Chi-Ming, Wu, Jen-Chine, Chen, Chien-Shu, Huang, Shih-Hao, Hwang, Jaulang, Cheng, Kur-Ta, Leiw, Phui-Ly, Chen, Chi-Long, Lin, Chun-Mao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514822/
https://ncbi.nlm.nih.gov/pubmed/26207989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132579
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