Novel fluoroindenoisoquinoline non-camptothecin topoisomerase I inhibitors

Contrary to other anticancer targets, topoisomerase I (TOP1) is targeted by only one chemical class of FDA-approved drugs: topotecan and irinotecan, the derivatives of the plant alkaloid, camptothecin. The indenoisoquinolines LMP400, LMP744 and LMP776 are novel non-camptothecin TOP1 inhibitors in cl...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Marzi, Laetitia, Agama, Keli, Murai, Junko, Difilippantonio, Simone, James, Amy, Peer, Cody J., Figg, William D., Beck, Daniel, Elsayed, Mohamed. S. A., Cushman, Mark, Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072611/
https://ncbi.nlm.nih.gov/pubmed/29748210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0028
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