Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors

BACKGROUND: The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-ligation. Attempts at new derivative designs for TopI inhibition are enthusiastic...

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Detalhes bibliográficos
Main Authors: Tsai, Hsiang-Ping, Lin, Li-Wei, Lai, Zhi-Yang, Wu, Jui-Yu, Chen, Chiao-En, Hwang, Jaulang, Chen, Chien-Shu, Lin, Chun-Mao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898767/
https://ncbi.nlm.nih.gov/pubmed/20565729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-49
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