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Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors
BACKGROUND: The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-ligation. Attempts at new derivative designs for TopI inhibition are enthusiastic...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898767/ https://ncbi.nlm.nih.gov/pubmed/20565729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-49 |
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