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The mechanism of topoisomerase I poisoning by a camptothecin analog
We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent Topotecan. Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (−1) and downstream (+...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137726/ https://ncbi.nlm.nih.gov/pubmed/12426403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242259599 |
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