The mechanism of topoisomerase I poisoning by a camptothecin analog

We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent Topotecan. Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (−1) and downstream (+...

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Bibliographic Details
Main Authors: Staker, Bart L., Hjerrild, Kathryn, Feese, Michael D., Behnke, Craig A., Burgin, Alex B., Stewart, Lance
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC137726/
https://ncbi.nlm.nih.gov/pubmed/12426403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242259599
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