The mechanism of topoisomerase I poisoning by a camptothecin analog

We report the x-ray crystal structure of human topoisomerase I covalently joined to double-stranded DNA and bound to the clinically approved anticancer agent Topotecan. Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (−1) and downstream (+...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Staker, Bart L., Hjerrild, Kathryn, Feese, Michael D., Behnke, Craig A., Burgin, Alex B., Stewart, Lance
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137726/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12426403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.242259599
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