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Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ
We report that disruption of the mouse TOP3β gene encoding DNA topoisomerase IIIβ, one of the two mammalian type IA DNA topoisomerases, leads to a progressive reduction in fecundity. The litter size in crosses of top3β(−/−) mice decreases over time and through successive generations, and this decrea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151374/ https://ncbi.nlm.nih.gov/pubmed/12591952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437998100 |
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