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Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ

We report that disruption of the mouse TOP3β gene encoding DNA topoisomerase IIIβ, one of the two mammalian type IA DNA topoisomerases, leads to a progressive reduction in fecundity. The litter size in crosses of top3β(−/−) mice decreases over time and through successive generations, and this decrea...

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Bibliografski detalji
Glavni autori: Kwan, Kelvin Y., Moens, Peter B., Wang, James C.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC151374/
https://ncbi.nlm.nih.gov/pubmed/12591952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437998100
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